Our findings distinguish pruning from pathological neurite degeneration, which is often induced by defects in energy production, and highlight how metabolism is adapted to fit energy-costly developmental transitions.ĪMPK dendrite proteasome pruning pyruvate translation.Ĭopyright © 2021 The Author(s). Neurons elaborate distinct dendritic patterns to facilitate the formation of synaptic connections and the innervation of epithelial tissues by sensory neurons. Ubiquitin-proteasome system (UPS) regulates different types of neurite pruning. Epigenetic factors regulate Sox14 expression and dendrite pruning in ddaC neurons. A genetic pathway composed of Sox14 and Mical governs dendrite pruning in ddaC neurons. Loss of AMPK or mitochondrial deficiency causes specific defects in pruning factor translation and the ubiquitin-proteasome system. Ecdysone signalling is the master regulator of dendrite pruning in ddaC neurons. Keywords: Basigin, dendrite morphogenesis, Drosophila, dendritic arborization neurons, sensory neuron, dendrite-substrate interaction Citation: Shrestha BR, Burgos A and Grueber WB (2021) The Immunoglobulin Superfamily Member Basigin Is Required for Complex Dendrite Formation in Drosophila. AMPK is activated by ecdysone and promotes oxidative phosphorylation and pyruvate usage, likely to enable neurons to use noncarbohydrate metabolites such as amino acids for energy production. We find that AMP-activated protein kinase (AMPK), a regulator of energy homeostasis, is cell-autonomously required for dendrite pruning. Metamorphosis is a nonfeeding stage that imposes metabolic constraints on development. The multiple dendrite neurons form the third distinctive type of. The diversity and complexity of Drosophila da neurons are ideal for studying neuronal fate determination, dendritedendrite interactions and dendritesubstrate interplay 2, 5. Many neuronal classes establish subtype-specific, highly stereotyped dendritic branching patterns to cover their receptive field (Lefebvre et al., 2015). md neurons display a variety of axon projections and possible sensory functions. The dendritic arborization (da) neurons of the peripheral sensory system in Drosophila larvae are a model system used to study dendritic arborization. To reshape neuronal connectivity in adult stages, Drosophila sensory neurons prune their dendrites during metamorphosis using a genetic degeneration program that is induced by the steroid hormone ecdysone. Sensory perception relies on properly differentiated and connected neurons for accurate processing of inputs.
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